Publications - The Martin LabThe Martin Lab

121. Slingerland, C.J., Lysenko, V., Chaudhuri, S., Wesseling, C., Barnes, D., Masereeuw, R., Martin, N.I. (2023) Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity. RSC Medicinal Chemistry, (accepted in press).
DOI: 10.1039/D3MD00456B.

120. Fellner, M., Walsh, A., Dela Ahator, S., Aftab, N., Sutherland, B., Tan, E.W., Bakker, A.T., Martin, N.I., van der Stelt, M., Lentz, C.S. (2023) Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response. ACS Infectious Diseases, (accepted in press).
DOI: 10.1021/acsinfecdis.3c00246.

119. van der Meij, A., Elsayed, S.S, Du, C., Willemse, J., Wood, T.M., Martin, N.I., Raaijmakers, J.M., van Wezel, G.P. (2023) The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes. Applied and Environmental Microbiology, (accepted in press).
DOI: 10.1128/aem.01239-23.

118. Mullowney, M.W., Duncan, K.R., Elsayed, S.S., Garg, N., van der Hooft, J.J.J., Martin, N.I., Meijer, D., Terlouw, B.R., Biermann, F., Blin, K., Durairaj, J., Gorostiola González, M., Helfrich, E.J.N., Huber, F., Leopold-Messer, S., Rajan, K., de Rond, T., van Santen, J.A., Sorokina, M., Balunas, M.J., Beniddir, M.A., van Bergeijk, D.A., Carroll, L.M., Clark, C.M., Clevert, D.-A., Dejong, C.A., Du, C., Ferrinho, S., Grisoni, F., Hofstetter, A., Jespers, W., Kalinina, O.V., Kautsar, S.A., Kim, H., Leao, T.F., Masschelein, J., Rees, E.R., Reher, R., Reker, D., Schwaller, P., Segler, M., Skinnider, M.A., Walker, A.S., Willighagen, E.L., Zdrazil, B., Ziemert, N., Goss, R.J.M., Guyomard, P., Volkamer, A., Gerwick, W.H., Kim, H.U., Müller, R., van Wezel, G.P., van Westen, G.J.P., Hirsch, A.K.H., Linington, R.G., Robinson, S.L., and Medema, M.H. (2023) Artificial intelligence for natural product drug discovery, Nature Reviews Drug Discovery, (accepted in press).
DOI: 10.1038/s41573-023-00774-7.

117. Bhin, J., Yemelyanenko, J., Chao, X., Klarenbeek, S., Opdam, M., Malka, Y., Hoekman, L., Kruger, D., Bleijerveld, O., Brambillasca, C.S., Sprengers, J., Siteur, B., Annunziato, S., van Haren, M.J., Martin, N.I., van de Ven, M., Peters, D., Agami, R., Linn, S.C., Boven, E., Altelaar, M., Jonkers, J., Zingg, D., and Wessels, L.F.A. (2023) MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer, Journal of Experimental Medicine. 220: e20211743
DOI: 10.1084/jem.20211743.

116. Bobylev, E.O., Knol, R.O., Mathew, S., Poole, D.A., Kotsogianni, I., Martin, N.I., de Bruin, B., Kros, A., Reek, J.N.H. (2023) In vivo Biodistribution of Kinetically Stable Pt2L4 Nanospheres that Show Anti-Cancer Activity. Chemical Science, (accepted in press).
DOI: 10.1039/D3SC01086D.

115. Buijs, N.P., Matheson, E., *Cochrane, S.P., *Martin, N.I. (2023) Targeting membrane-bound bacterial cell wall precursors: A tried and true antibiotic strategy in nature and the clinic. Chemical Communications, (accepted in press).
DOI: 10.1039/D3CC01070H.

114. Hutten, S.J., de Bruijn, R., Lutz, C., Badoux, M., Eijkman, T., Chao, X., Ciwinska, M., Sheinman, M., Messal, H., Herencia-Ropero, A., Kristel, P., Mulder, L., van der Waal, R., Sanders, J., Almekinders, M.M., Llop-Guevara, A., Davies, H.R., van Haren, M.J., Martin, N.I., Behbod, F., Nik-Zainal, S., Serra, V., van Rheenen, J., Lips, E.H., Wessels, L.F.A., Wesseling, J., Scheele, C.L.G.J., and Jonkers, J. (2023) A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression, Cancer Cell 41, 986-1002. e1009.
DOI: 10.1016/j.ccell.2023.04.002.

113. Al Ayed, K., Zamarbide Losada, D., Machushynets, N.V., Terlouw, B., Elsayed, S.S., Schill, J., Trebosc, V., Pieren, M., Medema, M.H., van Wezel, G.P., *Martin, N.I. (2023) Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability. ACS Infectious Diseases, (accepted in press).
DOI: 10.1021/acsinfecdis.3c00043.

112. Ballantine, R.D., Al Ayed, K., Bann, S.J., Hoekstra, M., *Martin, N.I., *Cochrane, S.A. (2023) Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity. Journal of Medicinal Chemistry, (accepted in press).
DOI: 10.1021/acs.jmedchem.3c00308.

111. Deisinger, J.P., Arts, M., Kotsogianni, I., Puls, J-S., Grein, F., Ortiz-López, F.J., Martin, N.I., Müller, A., Genilloud, O., Schneider, T. (2023) Dual targeting of the class V lanthipeptide antibiotic Cacaoidin. iScience, (accepted in press).
DOI: 10.1016/j.isci.2023.106394.

110. Bakker, A.T., Kotsogianni, I., Mirenda, L., Straub, V.M., Avalos, M., van den Berg, R., Florea, B.I., van Wezel, G.P., Janssen, A., *Martin, N.I., *van der Stelt, M. (2023) Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society, 145, 1136–1143.
DOI: 10.1021/jacs.2c10819.

109. Javed, A., Slingerland, C.J., Wood, T.M., Martin, N.I., Broere, F., Weingarth, M.H., Veldhuizen, E.J.A. (2023) Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS Infectious Diseases, 9, 518-526.
DOI: 10.1021/acsinfecdis.2c00518.

108. Slingerland, C.J., Wesseling, C.J., Innocenti, P., Westphal, K.G.C., Masereeuw, R., *Martin, N.I. (2022) Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids. Journal of Medicinal Chemistry, 65, 15878–15892.
DOI: 10.1021/acs.jmedchem.2c01528.

107. Slingerland, C.J., Kotsogianni, I., Wesseling, C.J., *Martin, N.I. (2022) Polymyxin Stereochemistry and Its Role in Antibacterial Activity and Outer Membrane Disruption. ACS Infectious Diseases, 8, 2396–2404.
DOI: 10.1021/acsinfecdis.2c00307.

106. Wade, N., Wesseling, M.J., Innocenti, P., Slingerland, C.J., Koningstein, G.M., Luirink, J., *Martin, N.I. (2022) Synthesis and Structure–Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494. ACS Infectious Diseases, 8, 2242−2252.
DOI: 10.1021/acsinfecdis.2c00459.

105. Buijs, N., Vlaming, H.C., van Haren, M.J., *Martin, N.I. (2022) Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups. ChemBioChem, 23, e202200547.
DOI: 10.1002/cbic.202200547.

104. Ballantine, R.D., Al Ayed, K., Bann, S.J., Hoekstra, M., *Martin, N.I., *Cochrane, S.A., (2022) Synthesis and Structure-Activity Relationship Studies of N-Terminal Analogues of the Lipopeptide Antibiotics Brevicidine and Laterocidine. RSC Medicinal Chemistry, 13, 1640-1643.
DOI: 10.1039/D2MD00281G.

103. Wesseling, C.M.J., *Martin, N.I. (2022) Synergy by Perturbing the Gram-negative Outer Membrane: Opening the Door for Gram-positive Specific Antibiotics. ACS Infectious Diseases, 8, 1731–1757.
DOI: 10.1021/acsinfecdis.2c00193.

102. van Groesen, E., Innocenti, P., *Martin, N.I. (2022) Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics (2014-2022). ACS Infectious Diseases, 8, 1381–1407.
DOI: 10.1021/acsinfecdis.2c00253.

101. Zhang, Y., van Haren, M.J., Marechal, N., Troffer-Charlier, N., Cura. V., Cavarelli, J., *Martin, N.I. (2022) Direct Assay for Measuring the Activity and Inhibition of Coactivator-Associated Arginine Methyltransferase 1. Biochemistry, 61, 1055–1063.
DOI: 10.1021/acs.biochem.2c00075.

100. Dahdouh, E., Allander, L., Falgenhauer, L., Iorga, B.I., Lorenzetti, S., Marcos-Alcalde, Í., Martin, N.I., Martínez-Martínez, L, Mingorance, J., Naas, T., Rubin, J.E., Spyrakis, F., Tängdén, T., Gómez-Puertas. P. (2022) Computational Modeling and Design of New Inhibitors of Carbapenemases: A Discussion from the EPIC Alliance Network. International Journal of Molecular Sciences, 23, 9746.
DOI: 10.3390/ijms23179746.

99. Versloot, R.C.A., Lucas, F.L.R., Yakovlieva, L., Tadema, M.J., Zhang, Y., Wood. T.M., Martin, N.I., Marrink, S.J., Walvoort, M.T.C., Maglia, G. (2022) Quantification of Protein Glycosylation Using Nanopores. Nano Letters, 22, 5357–5364.
DOI: 10.1021/acs.nanolett.2c01338.

98. Hansenová, S.H., Nazmi, K., van’t Hof, W., van Belkum, A., Kaman, W.E., Martin, N.I., Veerman, E.C.I., Bikker, F.J. (2022) Natural and Synthetic Sortase A Substrates Are Processed by Staphylococcus aureus via Different Pathways. Bioconjugate Chemistry, 33, 555-559.
DOI: 10.1021/acs.bioconjchem.2c00012.

97. Al Ayed, K., Ballantine, R.D., Hoekstra, M., Bann, S.J., Wesseling, C.M.J., Bakker, A.T., Zhong, Z., Li, Y-X., Brüchle, N.C., van der Stelt, M., *Cochrane, S.A., *Martin, N.I. (2022) Synthetic Studies with the Brevicidine and Laterocidine Lipopeptide Antibiotics Including Analogues with Enhanced Properties and in vivo Efficacy. Chemical Science, 13, 3563-3570. DOI: 10.1039/D2SC00143H.

96. Wood, T.M., Zeronian, M.R., Buijs, N., Bertheussen, K., Abedian, H.K., Johnson, A.V., Pearce, N.M., Lutz, M., Kemmink, J., Seirsma, T., Hamoen, L.W., *Janssen, B.J.C. *Martin, N.I. (2022) Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures. Chemical Science, 13, 2985-2991.
DOI: 10.1039/D1SC07190D.

95. Wesseling, C.M.J., Slingerland, C.J., Veraar, S., Lok, S., *Martin, N.I. (2021) Structure-activity studies with bis-amidines that potentiate Gram-positive specific antibiotics against Gram-negative pathogens. ACS Infectious Diseases, 7, 3314-3335.
DOI: 10.1021/acsinfecdis.1c00466.

94. Zhang, Y., Marechal, N., van Haren, M.J., Troffer-Charlier, N., Cura, V., *Cavarelli, J., *Martin, N.I. (2021) Structural studies provide new insights into the role of lysine acetylation on substrate recognition by CARM1 and inform the design of potent peptidomimetic inhibitors. ChemBioChem, 22, 3469-3476.
DOI: 10.1002/cbic.202100506.

93. van Haren, M.J., Zhang, Y., Thijssen, V., Buijs, N., Gao, Y., Mateuszuk, L., Fedak, F.A., Kij, A., Campagna, R., Sartini, D., Emanuelli, M., Chlopicki, S.,*Jongkees, S.A.K., *Martin, N.I. (2021) Macrocyclic Peptides as Allosteric Inhibitors of Nicotinamide N-Methyltransferase (NNMT). RSC Chemical Biology, 2, 1546-1555).
DOI: 10.1039/D1CB00134E.

92. van Haren, M.J., Gao, Y., Buijs, N., Campagna, R., Sartini, D., Emanuelli, M., Mateuszuk, L., Kij, A., Chlopicki, S., Escudé Martinez de Castilla, P., Schiffelers, R., *Martin, N.I. (2021) Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity. Biomolecules, 11, 1357. DOI: 10.3390/biom11091357.

91. Kotsogianni, I., Wood, T.M., Alexander, F., Cochrane, S.A., *Martin, N.I. (2021) Binding studies reveal phospholipid specificity and its role in the calcium-dependent mechanism of action of daptomycin. ACS Infectious Diseases, 7, 2612-2619. DOI: 10.1021/acsinfecdis.1c00316.

90. Gao, Y., van Haren, M.J., Buijs, N., Innocenti, P., Zhang, Y., Sartini, D., Campagna, R., Emanuelli, M., Parsons, R.B., Jespers, W., Gutiérrez-de-Terán, H., van Westen, G., *Martin, N.I. (2021) Potent inhibition of nicotinamide N-methyltransferase by alkene linked bisubstrate mimics bearing electron deficient aromatics. Journal of Medicinal Chemistry, 64, 12938-12963.
DOI: 10.1021/acs.jmedchem.1c01094.

89. van Groesen, E., Slingerland, C.J., Innocenti, P., Mihajlovic, M., Masereeuw, R., *Martin, N.I. (2021) Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates that Retain anti-Gram-Positive Activity with Enhanced Potency Against Gram-Negative Strains. ACS Infectious Diseases, 7, 2746-2754.
DOI: 10.1021/acsinfecdis.1c00318.

88. Wood, T.M., Slingerland, C.J. *Martin, N.I. (2021) A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-negative Pathogens. Journal of Medicinal Chemistry, 64, 10890–10899.
DOI: 10.1021/acs.jmedchem.1c00176.

87. Tehrani, K.H.M.E., Wade, N., Mashayekhi, V., Brüchle, N., Jespers, W., Voskuil, K., Pesce, D., van Haren, M.J., van Westen, G.J.P., *Martin, N.I. (2021) Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases. Journal of Medicinal Chemistry, 64, 9141–9151. DOI: 10.1021/acs.jmedchem.1c00362.

86. Gao, J.,*Martin, N.I., *van Haren, M.J. (2021) Nicotinamide N-Methyl Transferase (NNMT): An Emerging Therapeutic Target. Drug Discovery Today, 26, 2699-2706. DOI: 10.1016/j.drudis.2021.05.011.

85. Sychantha, D., Rotondo, C.M., Tehrani, K.H.M.E., Martin, N.I., Wright, G.D. (2021) Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn²⁺. Journal of Biological Chemistry, 297, 100918. DOI: 10.1016/j.jbc.2021.100918.

84. Steenhuis, M., Ulsen, P., Martin, N.I., Luirink, J. (2021) A Ban on BAM: An Update on Inhibitors of the β-barrel Assembly Machinery. FEMS Microbiology Letters, 368, fnab059. DOI: 10.1093/femsle/fnab059.

83. Wesseling, C., Wood, T.M., Slingerland, C.J., Bertheussen, K., Lok, S., *Martin, N.I. (2021) Thrombin-derived peptides potentiate the activity of Gram-positive-specific antibiotics against Gram-negative bacteria. Molecules, 26, 1954. DOI: 10.3390/molecules26071954.

82. van der Woude, L, Piotrowski, M., Klaasse, G., Paulus, J.K., Krahn, D., Ninck, S., Kaschani, F., Kaiser, M., Novák, O., Ljung, K., Bulder, S., Van Verk, M., Snoek, B.L., Fiers, M., Martin, N.I. van der Hoorn, R.A.L., Robert, S., Smeekens, S., van Zanten, M. (2021) The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1‐subfamily of nitrilases. The Plant Journal, 106, 1523-1540. DOI: 10.1111/tpj.15250.

81. Ignacio, B.J., Bakkum, T., Bonger, K.M., Martin, N.I., van Kasteren, S.I. (2021) Metabolic Labeling Probes for Interrogation of The Host-Pathogen Interaction. Organic and Biomolecular Chemistry, 19, 2856-2870.
DOI: 10.1039/D0OB02517H.

80. Wade, N., Tehrani, K.H.M.E., Brüchle, N., van Haren, M.J., Mashayekhi, V., *Martin, N.I. (2021) Mechanistic Investigations of Metallo-β-Lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition. ChemMedChem 16, 1651-1659.
DOI: 10.1002/cmdc.202100042.

79. van Haren, M.J., Tehrani, K.H.M.E., Kotsogianni, I., Wade, N., Brüchle, N., Mashayekhi, V., *Martin, N.I. (2021) Cephalosporin prodrug inhibitors overcome metallo-β-lactamase driven antibiotic resistance. Chemistry-A European Journal, 27, 3806-3811.
DOI: 10.1002/chem.202004694.

78. Yakovlieva, L., Wood, T.M., Kemmink, J., Kotsogianni, I., Krafczyk, R., Lassak, J.,*Martin, N.I.,*Walvoort, M.T.C. (2021) A β-Hairpin Epitope as Novel Structural Requirement for Protein Arginine Rhamnosylation. Chemical Science, 12, 1560-1567.
DOI: 10.1039/D0SC05823H.

77. Tehrani, K.H.M.E., Brüchle, N.C., Wade, N., Mashayekhi, V., Pesce, D., van Haren, M.J., *Martin, N.I. (2020) Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem. ACS Infectious Diseases, 6, 1366-1371.
DOI: 10.1021/acsinfecdis.9b00459.

76. Diehl, A., Wood, T.M., Gebhard, S., Martin, N.I., Fritz, G. (2020) The Cell Envelope Stress Response of Bacillus subtilis towards Laspartomycin C. Antibiotics, 9, 729. DOI: 10.3390/antibiotics9110729.

75. Tehrani, K.H.M.E., Fu, H., Brüchle, N.C., Mashayekhi, V., Luján, A.P., van Haren, M.J., *Poelarends, G.J., *Martin, N.I. (2020) Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1. Chemical Communications, 56, 3047-3049.
DOI: 10.1039/D0CC00356E.

74. Wood, T.M., Bertheussen, K., *Martin, N.I. (2020) The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics. Organic and Biomolecular Chemistry, 18, 514-517.
DOI: 10.1039/C9OB02534K.

73. Chiorean, S., Antwi, I., Carney, D.W., Kotsogianni, I., Giltrap, A.M., Alexander, F.M., Cochrane, S.A., Payne, R.J., Martin, N.I., Henninot, A., Vederas, J.C. (2020) Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II. ChemBioChem, 21, 789-792.
DOI: 10.1002/cbic.201900504.

72. Zhang, Y., van Haren, M.J., *Martin, N.I. (2020) Peptidic transition state analogues as PRMT inhibitors. Methods, 175, 24-29.
DOI: 10.1016/j.ymeth.2019.08.003.

71. Gao, Y., van Haren, M.J., Moret, E.E., Rood, J.J.M., Sartini, D., Salvucci, A., Emanuelli, M., Craveur, P., Babault, N., Jin, J., *Martin, N.I. (2019) Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity. Journal of Medicinal Chemistry, 62, 6597-6614.
DOI: 10.1021/acs.jmedchem.9b00413.

70. Brouwer, M.S.M., Tehrani, K.H.M.E., Rapallini, M., Geurts, Y., Kant, A., Harders, F., Mashayekhi, V., Martin, N.I., Bossers, A., Mevius, D.J., Wit, B., Veldman, K.T. (2019) Novel carbapenemase FLC-1 and IMI-2 encoded by an Enterobacter cloacae complex. Antimicrobial Agents and Chemotherapy, 63, e02338-18.
DOI: 10.1128/AAC.02338-18.

69. van Haren, M.J., *Martin, N.I. (2019) PRMT Inhibitors (Book Chapter) Topics in Medicinal Chemistry, Springer Berlin Heidelberg.
DOI: 10.1007/7355_2019_73.

68. Wood, T.M., *Martin, N.I. (2019) The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry. MedChemComm, 10, 634 – 646.
DOI: 10.1039/C9MD00126C.

67. Heesterbeek, D.A.C., Martin, N.I., Velthuizen, A., Duijst, M., Ruyken, M., Wubbolts, R. Rooijakkers, S.H.M., Bardoel, B.W. (2019) Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics. Scientific Reports, 9, Article number: 3074.
DOI: 10.1038/s41598-019-38577-9.

66. Lin, M-H., Potel, C.M.,Tehrani, K.H.M.E., Heck, A.J.R. Martin, N.I., Lemeer, S. (2018) A new tool to reveal bacterial signaling mechanisms in antibiotic treatment and resistance. Molecular & Cellular Proteomics, 17, 2496-2507.
DOI: 10.1074/mcp.RA118.000880.

65. Tehrani, K.H.M.E., *Martin, N.I. (2018) β-lactam/β-lactamase inhibitor combinations: an update. MedChemComm, 9, 1439-1456.
DOI: 10.1039/C8MD00342D.

64. Bolt, H.L., Kleijn, L.H.J., *Martin, N.I., *Cobb, S.L. (2018) Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology. Molecules, 23, 1566-1565.
DOI: 10.3390/molecules23071566.

63. van Haren, M.J., Thomas, M.G., Sartini, D., Barlow, D.J., Ramsden, D.B., Emanuelli, M., Klamt, F., *Martin, N.I., *Parsons, R.B. (2018) The N-Methylation of 4-Phenylpyridine By Nicotinamide N-Methyltransferase Demonstrates Both Competitive And Substrate Inhibition. The International Journal of Biochemistry & Cell Biology, 98, 127-136.
DOI: 10.1016/j.biocel.2018.03.010.

62. Brown, J.I., Koopmans, T., van Strien, J., *Martin, N.I., *Frankel, A. (2018) Kinetic analysis of PRMT1 reveals multifactorial processivity and a sequential ordered mechanism. ChemBioChem, 19, 85-99.
DOI: 10.1002/cbic.201700521.

61. Bergstrom, A., Katko, A., Adkins, Z.B., Hill, J.E., Cheng, Z., Burnett, M.L., Yang, H., Aitha, M., Mehaffey, M.R., Brodbelt, J.S., Tehrani, K.H.M.E., Martin, N.I., Bonomo, R.A., Page, R.C., Tierney, D.L., Fast, W., Wright, G.D., Crowder, M.W. (2018) Probing the interaction of Aspergillomarasmine A (AMA) with metallo-β-lactamases NDM-1, VIM-2, and IMP-7. ACS Infectious Diseases, 4, 135-145.
DOI: 10.1021/acsinfecdis.7b00106.

60. Mena-Barragán, T., García-Moreno, M.I., Sevšek, A., Okazaki, T., Nanba, E., *Higaki, K., *Martin, N.I., *Pieters, R.J., *García Fernández, J.M., *Ortiz Mellet, C., (2018) Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human β-glucocerebrosidase: A picomolar chaperone for Gaucher disease. Molecules, 23, 927-945.
DOI: 10.3390/molecules23040927.

59. Kleijn, L.H.J., Vlieg, H.C., Wood, T.M., Sastre Toraño, J., *Janssen, B.J.C., *Martin, N.I. (2017) A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C. Angewandte Chemie International Edition, 129, 16773-16776.
DOI: 10.1002/anie.201709240.

58. Sevšek, A., Sastre Toraño, J., Quarles van Ufford, L., Moret, E.E., *Pieters, R.J., *Martin, N.I. (2017) Orthoester Functionalized N-Guanidino Derivatives of 1,5-dideoxy-1,5-imino-D-xylitol as pH-Responsive Inhibitors of β-Glucocerebrosidase. MedChemComm, 8, 2050-2054.
DOI: 10.1039/C7MD00480J.

57. ‘t Hart, P., Wood, T.M., Tehrani, K.H.M.E., van Harten, R.M., Śleszyńska, M., Rentero Rebollo, I., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., *Martin, N.I. (2017) De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria. Chemical Science, 8, 7991-7997.
DOI: 10.1039/C7SC03413J.

56. Tehrani, K.H.M.E., *Martin, N.I. (2017) Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem. ACS Infectious Diseases, 3, 711-717.
DOI: 10.1021/acsinfecdis.7b00094.

55. van Haren, M.J., Marechal, N.; Troffer-Charlier, N.; Cianciulli, A.; Sardella, G.; *Cavarelli, J.; *Martin, N.I. (2017) Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proceedings of the National Academy of Sciences USA, 114, 3625–3630.
DOI: 10.1073/pnas.1618401114.

54. van Haren, M.J., Taig, R., Kuppens, J., Sastre Toraño, J., Moret, E.E., Parsons, R.B., Sartini, D., Emanuelli, M., *Martin, N.I. (2017) Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state. Organic and Biomolecular Chemistry, 15, 6656-6667.
DOI: 10.1039/C7OB01357D.

53. Sevšek, A., Šrot, L., Rihter, J.; Čelan, M., Quarles van Ufford, L., Moret, E.E., *Martin, N.I., *Pieters, R.J. (2017) N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-D-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase. ChemMedChem, 12, 483–486.
DOI: 10.1002/cmdc.201700050.

52. Kleijn, L.H.J., *Martin, N.I. (2017) The Cyclic Lipopeptide Antibiotics (Book Chapter) Topics in Medicinal Chemistry, vol. 26, page 27-53. Springer Berlin Heidelberg.
DOI: 10.1007/7355_2017_9.

51. le Paige, U., Smits, B., ‘t Hart, P., Lefeber, F., Martin, N.I., van Ingen, H. (2017) Weak coupling between magnetically inequivalent spins: the deceptively simple, yet complicated spectrum of a 13C-labeled trimethylated amine. Journal of Magnetic Resonance, 278, 96-103.
DOI: http://dx.doi.org/10.1016/j.jmr.2017.03.016.

50. van Harten, R.M., Willems, R.J.L., Martin, N.I., Hendrickx, A.P.A. Multidrug Resistant Enterococcal Infections: (2017) New Compounds, Novel Antimicrobial Therapies? Trends in Microbiology, 25, 467–479.
DOI: 10.1016/j.tim.2017.01.004.

49. Oude Blenke, E., Sleszynska,M., Evers, M.J.W., Storm, G., Martin, N.I., Mastrobattista, E. (2017) Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger. Bioconjugate Chemistry, 28, 574–582.
DOI: 10.1021/acs.bioconjchem.6b00677.

48. Cura, V., Marechal, N., Troffer-Charlier, N., Strub, J-M., van Haren, M.J., Martin, N.I., Cianferani, S., Bonnefond, L., Cavarelli, J. (2017) Functional insights from structural studies of protein arginine methyltransferase 2. The FEBS Journal, 284, 77-96.
DOI: 10.1111/febs.13953.

47. van ‘t Veer, I.L., Leloup, N.O.L., Egan, A.J.F., Janssen, B.J.C., Martin, N.I., Vollmer, W., Breukink, E. (2016) Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem, 17, 2250-2256.
DOI: 10.1002/cbic.201600461.

46. Pagliero R.J., D’Astolfo D.S., Lelieveld D., Pratiwi R.D., Aits S., Jaattela M., Martin N.I., Klumperman J., and Egan D.A. (2016) Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform. ASSAY and Drug Development Technologies, 14, 489-510.
DOI: 10.1089/adt.2016.727.

45. van Haren, M.J., Sastre Toraño, J., Sartini, D., Emanuelli, M., Parsons, R.B., *Martin, N.I. (2016) A rapid and efficient assay for the characterization of substrates and inhibitors of nicotinamide N-methyltransferase. Biochemistry, 55, 5307-5315.
DOI: 10.1021/acs.biochem.6b00733.

44. Sevšek, A., Čelan, M., Erjavec, B., Quarles van Ufford, L., Sastre Toraño, J., Moret, E.E., *Pieters, R.J, *Martin, N.I. (2016) Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Organic and Biomolecular Chemistry, 14, 8670-8673.
DOI: 10.1039/C6OB01735E.

43. Thomas, M.G., Sartini, D., Emanuelli, M., van Haren, M.J., Martin, N.I., Mountford, D.M., Barlow, D.J., Klamt, F., Ramsden, D.B., Reza, M., Parsons, R.B. (2016) Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway. Biochemical Journal, 473, 3253-3267.
DOI: 10.1042/BCJ20160219.

42. Kleijn, L.H.J., Oppedijk, S.F., ‘t Hart, P., van Harten, R.M., Martin-Visscher, L.A., Kemmink, J., Breukink, E., *Martin, N.I. (2016) Total synthesis of Laspartomycin C and characterization of its antibacterial mechanism of action. Journal of Medicinal Chemistry, 59, 3569–3574.
DOI: 10.1021/acs.jmedchem.6b00219.

41. ‘t Hart, P., Oppedijk, S.F., Breukink, E., *Martin, N.I. (2016) New insights into nisin’s antibacterial mechanism revealed by binding studies with synthetic lipid II analogues. Biochemistry, 55, 232–237.
DOI: 10.1021/acs.biochem.5b01173.

40. Maňásková, S.H., Nazmi, K., van ’t Hof, W., van Belkum, A., Martin, N.I., Bikker, F.J., van Wamel, W.J.B., Veerman, E.C.I. (2016) Staphylococcus aureus Sortase A-mediated incorporation of peptides: Effect of peptide modification on incorporation. PLoS ONE, 11, e0147401.
DOI: 10.1371/journal.pone.0147401.

39. Oppedijk, S.F., Martin, N.I. Breukink, E. (2016) Hit ‘em where it hurts: the growing and structurally diverse family of peptides that target lipid-II. Biochimica et Biophysica Acta. Biomembranes, 1858, 947–957.
DOI: 10.1016/j.bbamem.2015.10.024.

38. Koopmans, T., Wood, T.M., ‘t Hart, P., Kleijn, L.H.J., Hendrickx, A.P.A., Willems, R.J.L., Breukink, E., *Martin, N.I. (2015) Semisynthetic lipopeptides derived from nisin display antibacterial activity and lipid II-binding on par with that of the parent compound. Journal of the American Chemical Society, 137, 9382–9389.
DOI: 10.1021/jacs.5b04501.

37. van Haren, M., Quarles van Ufford, L., Moret, E.E., *Martin, N.I. (2015) Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites. Organic and Biomolecular Chemistry, 13, 549-560.
DOI: 10.1039/C4OB01734J.

36. Corradini, E., Klaasse, G., Leurs, U., Heck, A.J.R., *Martin, N.I., *Scholten, A. (2015) Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach. Molecular Biosystems, 11, 2786-2797.
DOI: 10.1039/C5MB00142K.

35. Oude Blenke, E., Klaasse, G., Merten, H., Plückthun, A., Mastrobattista, E., *Martin, N.I. (2015) Liposome functionalization with copper-free “Click Chemistry”. Journal of Controlled Release, 202, 14-20.
DOI: 10.1016/j.jconrel.2015.01.027.

34. Gruba, N., Wysocka, M., Brzezińska, M., Debowski, D., Rolka, K., Martin, N.I., Lesner, A. (2015) Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome. Analytical Biochemistry, 508, 38-45.
DOI: 10.1016/j.ab.2015.08.019.

33. Thomas, D., Koopmans, T., Lakowski, T.M., Kreinin, H., Bui, J.M., Vhuiyan, M.I., *Martin, N.I., *Frankel, A. (2014) Protein arginine N-methyltransferase substrate preferences for different N(eta)-substituted arginyl peptides. ChemBioChem, 15, 1607-1613.
DOI: 10.1002/cbic.201402045.

32. Mooney, C.A., Johnson, S.A., ‘t Hart, P., Quarles van Ufford, L., de Haan, C.A.M., Moret, E.E., *Martin, N.I. (2014) Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors. Journal of Medicinal Chemistry, 57, 3154-3160.
DOI: 10.1021/jm401977j.

31. Mohammadi, T., Sijbrandi, R., Lutters, M., Verheul, J., Martin, N.I., den Blaauwen, T., de Kruijff, B., Breukink, E. (2014) Specificity of the transport of lipid II by FtsW in Escherichia coli. The Journal of Biological Chemistry, 289, 14707-14718. DOI: 10.1074/jbc.M114.557371.

30. ‘t Hart P., Kleijn, L.H.J., de Bruin, G., Oppedijk, S.F., Kemmink, J., *Martin, N.I. (2014) A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics. Organic and Biomolecular Chemistry, 12, 913-918. Manuscript designated as an “OBC Hot Article” for month of January 2014.
DOI: 10.1039/C3OB42238K.

29. Dekker, F.J., van den Bosch, T., Martin, N.I. (2014) Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. Drug Discovery Today, 19, 654-660.
DOI: 10.1016/j.drudis.2013.11.012.

28. van Wandelen, L., van Ameijde, J., Ismail-Ali, A., Quarles van Ufford, L., Vijftigschild, L., Beekman, J., Martin, N.I., Ruijtenbeek, R., Liskamp, R.M.J. (2013) Cell-penetrating bisubstrate-based protein kinase C inhibitors. ACS Chemical Biology, 8, 1479-1487.
DOI: 10.1021/cb300709g.

27. Kooij, R., Branderhorst, H.M., Bonte, S., Wieclawska, S., *Martin, N.I., *Pieters, R.J. (2013) Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives. MedChemComm, 4, 387-393.
DOI: 10.1039/C2MD20343J.

26. Koopmans, T., van Haren, M., Quarles van Ufford, L., Beekman, J., *Martin N.I. (2013) A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis. Bioorganic and Medicinal Chemistry, 21, 553-559.
DOI: 10.1016/j.bmc.2012.10.055.

25. Van Hattum, H., Martin, N.I., Ruijtenbeek, R., Pieters, R.J. (2013) Development of a microarray detection method for galectin cancer proteins based on ligand binding. Analytical Biochemistry, 434, 99-104.
DOI: 10.1016/j.ab.2012.11.003.

24. Kleijn, L.H.J., Müskens, F.M., Oppedijk, S.F., de Bruin, G., *Martin, N.I. (2012) A concise preparation of the non-proteinogenic amino acid L-kynurenine. Tetrahedron Letters, 53, 6430-6432.
DOI: 10.1016/j.tetlet.2012.09.055.

23. ‘t Hart P., Thomas, D., van Ommeren, R., Lakowski, T.M., *Frankel, A., *Martin, N.I. (2012) Analogues of the HIV-Tat peptide containing N^η-modified arginines as potent inhibitors of protein arginine N-methyltransferases. MedChemComm, 3, 1235-1244.
DOI: 10.1039/C2MD20161E.

22. Koopmans, T., Dekker, F.J., *Martin, N.I. (2012) A photocleavable affinity tag for the enrichment of alkyne-modified biomolecules. RSC Advances, 2, 2244-2246.
DOI: 10.1039/C2RA20082A.

21. ‘t Hart P, Lakowski, T.M., Thomas, D., *Frankel, A., *Martin, N.I. (2011) Peptidic partial-bisubstrates as inhibitors of the protein arginine N-methyltransferases. ChemBioChem, 12, 1427-1432.
DOI: 10.1002/cbic.201100074.

20. Olrichs, N.K., Aarsman, M.E.G., Verheul, J. Arnusch, C.J., Martin, N.I., Herve, M., Vollmer, W., de Kruijff, B., Breukink, E., den Blaauwen, T.A. (2011) A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli. ChemBioChem, 12, 1124-1133.
DOI: 10.1002/cbic.201000552.

19. Lakowski, T.M., ‘t Hart P. Ahern, C.A. *Martin, N.I., *Frankel, A. (2010) N^η-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases. ACS Chemical Biology, 5, 1053-1063.
DOI: 10.1021/cb100161u.

18. *Martin, N.I. (2009) Concise preparation of tetra-orthogonally protected (2S,6R)-lanthionines. The Journal of Organic Chemistry, 74, 946-949.
DOI: 10.1021/jo802415c.

17. Woodward, J.J., Chang, M.M., Martin, N.I. and Marletta, M.A. (2009) The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant. Journal of the American Chemical Society, 131, 297-305.
DOI: 10.1021/ja807299t.

16. Martin, N.I., Woodward, J.J., Winter, M.B., and Marletta, M.A. (2009) 4,4-Difluorinated analogues of L-arginine and N^G-hydroxy-L-arginine as mechanistic probes for nitric oxide synthase. Bioorganic and Medicinal Chemistry Letters, 19, 1758-1762.
DOI: 10.1016/j.bmcl.2009.01.076.

15. *Martin, N.I. and Liskamp, R.M.J. (2008) Preparation of N^G-substituted L-arginine analogues suitable for solid phase peptide synthesis. The Journal of Organic Chemistry, 73, 7849-7851.
DOI: 10.1021/jo801517f.

14. Martin, N.I., Beeson, W.T., Woodward, J.J. and Marletta, M.A. (2008) N^G-Aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors. Journal of Medicinal Chemistry, 51, 924-931.
DOI: 10.1021/jm701119v.

13. Martin, N.I., Woodward, J.J., Winter, M.B., Beeson, W.T. and Marletta, M.A. (2007) Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase. Journal of the American Chemical Society, 129, 12563-12570.
DOI: 10.1021/ja0746159.

12. Martin, N.I. and Breukink, E. (2007) The expanding role of lipid II as a target for lantibiotics. Future Microbiology, 2, 513-525.
DOI: 10.2217/17460913.2.5.513.

11. Woodward, J.J., Martin, N.I. and Marletta, M.A. (2007) An Escherichia coli expression-based method for heme Substitution. Nature Methods, 4, 43-45.
DOI: 10.1038/nmeth984.

10. Martin, N.I., Derbyshire, E.R. and Marletta, M.A. (2007) Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorganic and Medicinal Chemistry Letters, 17. 4938-4941.
DOI: 10.1016/j.bmcl.2007.06.039.

9. Pattabiraman, V.R., Stymiest, J.L., Derksen, D.J., Martin, N.I. and Vederas, J.C. (2007) Multiple on-resin olefin metathesis to form ring expanded analogues of the lantibiotic peptide, lacticin 3147 A2. Organic Letters, 9. 699-702.
DOI: 10.1021/ol063133j.

8. *Martin, N.I., Woodward, J.J. and Marletta, M.A. (2006) N^G-Hydroxyguanidines from primary amines. Organic Letters, 8. 4035-4036. Paper featured on the organic chemistry web portal (www.organic-chemistry.org).
DOI: 10.1021/ol061454p.

7. Gursky, L.J., Martin, N.I., Derksen, D.J., van Belkum, M.J., Kaur, K., Vederas, J.C., Stiles, M.E. and McMullen, L.M. (2006) Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration. Archives of Microbiology. 186, 317-325.
DOI: 10.1007/s00203-006-0147-z.

6. Martin, N.I., Sprules, T., Carpenter, M.R., Cotter, P.D., Hill, C., Ross, R.P. and Vederas, J.C. (2004) Characterization of lacticin 3147, A two-peptide antibiotic with synergistic activity. Biochemistry. 43, 3049-3056.
DOI: 10.1021/bi0362065.

5. Martin, N.I., Hu, H., Moake, M.M., Churey, J.J., Whittal, R., Worobo, R.W. and Vederas, J.C. (2003) Isolation, structural characterization and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensis M. Journal of Biological Chemistry. 278, 13124 – 13132.
DOI: 10.1074/jbc.M212364200.

4. Garneau, S., Martin, N.I. and Vederas, J.C. (2002) Two-peptide bacteriocins produced by lactic acid bacteria. Biochimie. 84, 577-592.
DOI: 10.1016/S0300-9084(02)01414-1.

3. Ramtohul, Y.K., Martin, N.I., Silkin, L., James, M.N.H. and Vederas, J.C. (2002) Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14. Journal of the Chemical Society. Perkin Transactions 1. 1351-1359.
DOI: 10.1039/B202643K.

2. Ramtohul, Y.K., Martin, N.I., Silkin, L., James, M.N.G. and Vederas, J.C. (2001) Pseudoxazolones, a new class of inhibitors for cysteine proteinases: Inhibition of hepatitis A virus and human rhinovirus 3C proteinases. Journal of the Chemical Society Chemical Communications. 2740-2741.
DOI: 10.1039/B109095J.

1. Mahaffy, P.G., Martin, N.I., Newman, K.E., Hohn, B., Mikula, R.J. and Munoz, V.A. (1998) A novel matrix for non-intrusive environmental lead screening. Environmental Science and Technology. 32, 2467-2477.
DOI: 10.1021/es970699h.

Patents

9. Netherlands Priority Patent Application No. N2033609; Title: DNA gyrase inhibitors. Inventors: Bakker, A., Kotsogianni, I., van der Stelt, M., Martin, N.I., Ghilarov, D., Avalos, M., Punt, J.M., Liu, B., Piermarini, D., van Boeckel, C.A.A., van Wezel, G.P., van der Berg, R. Priority date: November 24, 2022.

8. Netherlands Priority Patent Application No. N2030897; Title: Antibiotic compounds, formulations and methods of use. Inventors: Slingerland, J., Martin, N.I. Priority date: February 11, 2022.

7. Netherlands Priority Patent Application No. N2029599; Title: Glycosylated Prodrugs. Inventors: Schaaf, M., Meijer, A., Halima, M., Wang, M., Aerts, H., Al Ayed, K., Martin, N.I. Priority date: November 2, 2021.

6. Netherlands Priority Patent Application No. N2027866; Title: Inhibitors of Nicotinamide N-Methyl Transferase (NNMT). Inventors: Martin, N.I., Gao, Y., van Haren, M.J., Buijs, N., Parsons, R.B., Emanuelli, M., Sartini, D. Priority date: March 30, 2021.

5. United Kingdom Priority Patent Application No. 2101165.5; Title: Antibiotic Natural Product Analogues. Inventors: Ballantine, R., Cochrane, S.A., Al Ayed, K., Martin, N.I. Priority date: January 28, 2021.

4. PCT patent application number: PCT/NL2020/050587; Title: A Novel Class of Lipidated Glycopeptide Antibiotics with Potent Antibacterial Activity. Inventors: Martin, N.I., van Groesen E., Tehrani, K.H.M.E., Wade, N. Priority date: September 24, 2019.

3. PCT patent application number: PCT/NL2020/050226; Titile: Prodrug metallo-beta-lactamase inhibitors. Inventors: Martin, N.I., van Haren M.J., Tehrani, K.H.M.E., Kotsogianni, I., Wade, N. Priority date: April 3, 2019.

2. PCT patent application number: PCT/EP2016/050827; Title: Nisin-based compounds and use thereof in the treatment of bacterial infections. Inventors: Martin, N.I., Koopmans T. Wood, T. Kleijn, L.H.J. Priority date: January 19, 2015.

1. PCT patent application number: PCT/NL2013/050562; Title: Urea and guanidinium derivatives of iminosugars. Inventors: Pieters, R.J.; Martin, N.I.; Branderhorst, H.M.; Kooij, R. Priority date: July 27, 2012.

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Nathaniel Martin